4 edition of Growth factor production by lymphoma cells found in the catalog.
Growth factor production by lymphoma cells
Thesis (M.Sc.)--University of Toronto, 1991.
|Series||Canadian theses = Thèses canadiennes|
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Autologous stem cell transplantation is a procedure in which a. there is a high rejection rate. b. stem cells are transferred to the patient from an HLA-matched donor. c. stem cells are transferred to the patient from an identical twin. d. stem cells are harvested from . f, Effects of concomitant pharmacological inhibition of PI3Kδ and GSK3β on in vitro growth of BCR + lymphoma cells (). Data refer to numbers (± s.e.m.) of treated tumour B cells .
Abstract. Connective tissue growth factor (CTGF) has a major role in development of fibrosis and in the wound-healing process. Microarray analysis of 44 classical Hodgkin lymphoma (cHL) samples showed higher CTGF messenger RNA expression in the nodular sclerosis (NS) than in the mixed cellularity (MC) subtype. When analyzed by immunohistochemical analysis, Hodgkin–Reed-Sternberg (H-RS) cells. Transforming growth factor-β (TGF-β) production in the tumor microenvironment is a potent and ubiquitous tumor immune evasion mechanism that inhibits the expansion and function of tumor-directed responses; therefore, we conducted a clinical study to discover the effects of the forced expression of a dominant-negative TGF-β receptor type 2 (DNRII) on the safety, survival, and activity of.
Establishment and comprehensive analysis of a new human transformed follicular lymphoma B cell line, Tat Leukemia. Feb;16(2) PMID: - PubMed: Smad7 is induced by CD40 and protects WEHI B-lymphocytes from transforming growth factor-beta -induced growth . "We also exposed our cells to epidermal growth factors (EGFs), which we know trigger the production of ILV after a cascade of reactions," says Aurélien Roux, Professor at UNIGE's Department of.
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Production of growth factors by malignant lymphoma cell lines. Tweeddale M(1), Jamal N, Nguyen A, Wang XH, Minden MD, Messner HA. Author information: (1)Ontario Cancer Institute, University of Toronto, by: Abstract. Fourteen Epstein-Barr virus (EBV)-negative cell lines were raised from bone marrow (BM), peripheral blood (PB), or lymph node samples of patients witCited by: One such factor, thought to be of T-cell origin, is distinguished by its ability to initiate and maintain continuous T-cell growth (T-cell growth factor, TCGF) 4– by: Cells of these lines were used to examine the growth factor requirements of their clonogenic progenitors and to assess their ability to produce their own growth factors.
Two of the cell lines (OCI-Ly9 and OCI-Ly) required addition of exogenous factors for colony by: The growth of activated human T lymphocytes in response to interleukin-2 Growth factor production by lymphoma cells book is suppressed by transforming growth factor-beta (TGF-beta). This study presents data that show a diminished response of two human lymphoma cell lines to physiologic regulation by TGF-beta.
Newcom SR, Kadin ME, Ansari AA. Production of transforming growth factor-beta activity by Ki-1 positive lymphoma cells and analysis of its role in the regulation of Ki-1 positive lymphoma growth.
Am J Pathol. Jun; (3)– [PMC free article] Newcom SR, Muth LH, Parker ET. Angiogenesis and mast cells in Hodgkin lymphoma. including vascular endothelial growth factor 9 and heparine. 6 Variations in the production and release of these factors by mast cells.
These results clearly indicate that the lost sensitivity of lymphoma cells toward a natural regulatory factor could be reversed. However the TGFβ induced effect is highly dependent on the actually expressed Smad signal inhibitors, survival factors and the lymphoma cell type.
Materials and methods Cells and cytokine treatment Interleukin 9 is a T-cell and mast cell growth factor that can also potentiate IL-4–induced IgG4 and IgE productionAlthough IL-9 mRNA was not detected in unstimulated L cells, it was identified in 5 of 12 (42%) cases of cHL by Northern analysis In 5 of these cases, including 2 that were IL-9 − by Northern analysis, IL-9 mRNA was.
IL-6 is a major growth factor for myeloma cells. 26 In advanced disease there is an excess of IL-6 production and raised serum concentrations are associated with plasmablastic proliferative activity and short survival. Shimizu S, Konaka Y, Smith RT. Mitogen-initiated synthesis and secretion of T cell growth factor(s) by a T-lymphoma cell line.
J Exp Med. Nov 1; (5)– [PMC free article] Smith KA, Gilbride KJ, Favata MF. Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells.
Nature. The normally supportive immune cells also start overproducing inflammation-promoting factors like cytokines and growth factors that promote blood vessel growth or.
Several growth factors (e.g. insulin-like growth factor 1, insulin-like growth factor 2, and TGF-β) produced by osteoblasts act as chemoattractants for cancer cells, as well as promote tumor growth and proliferation Other factors produced by osteoblasts (TNF-α, IL-1β) reduce cancer cell growth.
Introduction. It is well known that leukemia is divided into lymphocytic and myelocytic types, each of which can be acute or chronic; whereas lymphoma can be categorized into non-Hodgkin's and Hodgkin's lymphoma (with the presence of Reed-Sternberg cells) (The Leukemia and Lymphoma Society, ).Global epidemiologic studies over the past few years have demonstrated that the.
The tumor cells have a tendency to grow cohesively in the lymph node sinuses, mimicking metastatic tumors. The sub-types include anaplastic large cell lymphoma, ALK-positive, anaplastic large cell lymphoma, ALK-negative, and breast implant-associated anaplastic large cell lymphoma.
Introduction. Hypoxia-Inducible-Factors (HIFs) are a family of heterodimeric transcription factors that regulate expression of more than genes involved in the response to hypoxia.
1 HIF is important in cancer, as it regulates various oncogenic genes as well as genes involved in cell survival, proliferation, and migration. 1, 2 In tumors, the combination of tissue hypoxia and cell growth. The Leukemia-Lymphoma Cell Line Factsbook represents an essential reference manual for all of the well-characterized leukemia-lymphoma cell lines currently available.
It provides the most important facts, using the succinct and user-friendly format that has made the FactsBooks so popular with scientists and clinical researchers.
Introductory chapters provide background and Reviews: 1. The neural-epithelial interaction and nerve growth factor (NGF) production by cancer cells favor tumor progression by promoting both the growth of cancer cells and neurites. Neuroendocrine (NE) cells are part of the diffuse NE system and exhibit a combination of neuronal and endocrine features.
MYC is a transcription factor associated with a number of cellular functions (e.g., cell growth and proliferation, angiogenesis, protein synthesis, metabolism, and DNA replication) with a strong oncogeneic potential. 42 In human B-cell neoplasms, MYC rearrangements involving the t(8;14) is a hallmark in Burkitt lymphoma and present in the.
Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.
Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. Having too few neutrophils (neutropenia) can lead to serious or even life threatening infections.
If you become neutropenic from chemotherapy (chemo), you may be treated with injections of a white blood cell growth factor, such as filgrastim (Neupogen) or pegfilgrastim (Neulasta), to boost your neutrophil count.The cells are dividing at a constant rate resulting in an exp.
onential. increase in the number of cells present. This is known as t. he specific. growth rate and is represented mathematically by first order. kinetics. as the following: dX = (µ – k.
d)X. d. t. where X is the cell concentration, µ. is the cell growth rate, and. k. d. is.The researchers concluded “the effects of [Mistletoe extract] on the B-cell lymphoma cell line [WSU-1] were comparable to those of vincristine in all parameters” (Kovacs ).
Other laboratory studies found that mistletoe extract stops the growth of lymphoma cells and kills up to 92% of tumor cells .